Tipo Seminário: Seminário de Pós-Graduação
Palestrante(s): Carlos Alberto Bulant, Universidad Nacional del Centro
Horário/Local: 15:00-16:30(Auditorio B)
Coronary heart disease is one of the leading causes of death worldwide. Although several risk factors are well known; many lesions cannot be explained by these factors alone.
The hypothesis of arteries developing lesions due to its morphology, known as geometric risk factors and/or due to hemodynamic forces, has been raised more than thirty years ago. Although investigators have found connection between geometric/hemodynamic variables and lesions, there exists no quantifiable index that helps physicians to predict actual risks.
Even when a severe lesion is present, recent studies have found that some patients can develop collateral circulation to provide sufficient blood flow to the myocardium, thus avoiding ischemia. In turn, the gold standard for functional stenosis assessment is an invasive medical exam called Fractional Flow Reserve (FFR). Moreover, these studies are expensive, require highly qualify professionals and involve risks to the patient during intervention.
In this context, this presentation will review the main results of the Thesis, which main goals were:
(i) to fully characterize coronary arterial trees from a geometrical perspective, search for hereditary geometric features and correlations between morphology and disease;
(ii) to construct a modeling methodology for the estimation of FFR making use of computational fluid dynamic models built on top of patient-specific medical images of coronary arterial networks.